Biotech Ingredients Market - Forecast(2023 - 2028)

Biotech Ingredients Market Overview

Biotech ingredients market size is forecast to reach USD$2.8 billion by 2027 after growing at a CAGR of around 8.7% during 2022-2027. Biotech ingredients like cytokines, fusion proteins and therapeutic enzymes are chemical compounds made by microbes, like bacteria, yeast, algae and others that undergo several processes like genetic engineering, recombinant DNA technology and others to get a feasible molecule. One of the prominent trends that the market is rising demand for biotech flavors and fragrances due to the increased awareness amongst the consumers regarding the negative impact of synthetic products. The rapid growth of the pharmaceutical industry due to increasing demand for therapeutic drugs is fueling the biotech ingredients market growth. Furthermore, the cosmetic industry is also expected to drive the biotech ingredients industry during the forecast period due to the change in customer preference towards eco-friendly products.

COVID-19 Impact

Currently, due to the COVID-19 pandemic, there was an increase in demand of biotech industries. During the COVID-19 outbreak, there was a rise in demand for drugs active pharmaceutical ingredients (API), antibodies and others required by the patients. This rise in demand of pharma products increased the demand of biotech ingredients market as well, since biotech ingredients are used in pharmaceutical products like vaccines. For instance, mRNA-based fusion protein vaccine which is a biotech ingredient is used as covid-19 vaccine. But initially, during the widespread lockdowns and transportation restrictions, there were production shutdowns in almost every global pharmaceutical industry sector. This created a gap in demand and supply. Due to such supply constraints, India and other countries began investing in domestic manufacturing of the vaccine. As the COVID-19 pandemic spreads, there is huge demand of drugs, vaccines and antibodies which are made from biotech ingredients like microbial expression systems.

Report Coverage

The report: “Biotech Ingredients Market– Forecast (2022-2027)”, by IndustryARC, covers an in-depth analysis of the following segments of the Biotech Ingredients Market.

By Type: Active Pharmaceutical Ingredients, Biosimilars and Others

By Product: Monoclonal Antibodies, Cytokines, Fusion Proteins, Vaccines & Hormones, Therapeutic Enzymes, Blood Factors, Strength Fibers, Biofuels, and Others

By Expression Systems: Protein Expression Systems (Mammalian Expression Systems, Microbial Expression Systems, Yeast Expression Systems, Insect Expression Systems, Others), Plant Expression Systems, Transgenic Expression Systems

By End-Use Industry: Cosmetic Industry (Hair Care, Skin Care, Makeup-Concealers, Foundation, Eye Gel and Others) Food & Beverage Industry (External Use Syrups, Bakery Product, Alcohols, and Others), Agriculture Industry, Pharmaceuticals Industry (Drugs, Pharmacogenomics, Gene therapy, Genetic testing, and Others), Textile Industry (Improvement in natural fibers, Novel fibers, Biofabrics, and Others) and Others

By Geography: North America (USA, Canada, and Mexico), Europe (UK, Germany, France, Italy, Netherlands, Spain, Russia, Belgium, and Rest of Europe), Asia-Pacific (China, Japan, India, South Korea, Australia and New Zealand, Indonesia, Taiwan, Malaysia, and Rest of APAC), South America (Brazil, Argentina, Colombia, Chile, and Rest of South America), Rest of the World (Middle East, and Africa)

Key Takeaways

• Europe dominates the biotech ingredients market, owing to the increasing demand in the cosmetics industry in the region. The Europe beauty and personal care market is expected to grow due to demand of biotech products in skin and hair care segments made out of biotech ingredients like essential oils, and other plant extracts. This will drive the demand of biotech ingredients market.
• There is an increasing demand of active pharmaceutical ingredients (APIs) like cytokines, fusion proteins and others, which further drives the demand for biotech ingredients as they are used in making biological drugs due to their high potency to treat diseases.
• There is growing consumer awareness towards biotech ingredients because they are more sustainable and efficacious as compared to petroleum-based ingredients. Thus, driving the market growth.

Biotech Ingredients Market Segment Analysis – By Type

The active pharmaceutical ingredients segment held the largest share in the biotech ingredients market and is expected to grow at a CAGR of over 9.0% in the forecast period. Active pharmaceutical ingredients (API) are a substance or a combination of ingredients that are used in the manufacture of pharmaceutical as these ingredients directly impact disease. The increase in chronic diseases such as asthma, cancer, arthritis and others, which is the major reason that has led to an increase in the demand for drugs like cytokines, fusion proteins and others, which in turn has driven the growth of the global active pharmaceutical ingredients industry. The world’s leading cause of death was cardiovascular diseases, according to the WHO. Several research and development (R&D) activities are done by manufacturers, to produce better-quality, low-cost APIs that can help in the treatment of diseases which are beyond the scope of small molecule drugs. A developing country such as India is attracting generic drug manufacturers due to factors such as fast availability of biotech ingredients such as from microorganism and plant expression systems, seamless distributor network and others. Thus, there is a shift of manufacturing facilities of biotech pharmaceutical companies to developing countries for increasing production and reducing input costs. The APIs are widely used in many therapeutic applications such as are oncology, cardiovascular, respiratory disorders and others.

Biotech Ingredients Market Segment Analysis – By Product

The monoclonal antibodies segment held the largest share in the biotech ingredients market in 2021 and is growing at a CAGR of over 8% during the forecast period due to the growing demand for organic and herbal medicines for various diseases such as cancer, autoimmune diseases and others. The monoclonal antibodies are cloned from antibodies produced in the body and are used for the treatment of these fatal diseases. The main reason of using monoclonal antibodies in the treatment of these diseases is that they are taken from a biological source and can produce antibodies for the long term and are thus, used for the treatment of diseases like cancer. For instance, Truxima (rituximab), the first biosimilar monoclonal antibody to be approved for use in the UK in an oncology setting. The monoclonal antibodies (mAbs)  enhance passive immunity. Specially in the current pandemic, monoclonal antibody treatments are proven most effective within a few days of receiving a COVID-19 diagnosis. For example, sotrovimAb (approved on May 26, 2021) has proven to greatly reduce severity and death — 85% efficacy.

Biotech Ingredients Market Segment Analysis – By Expression Systems

Microbial expression systems are the fastest growing segment during the forecast period of the market. They are widely used in the production of antibodies and therapeutic proteins. The microbial expression systems are preferred due to properties such as low cost, high expression yield and others. Microbial fermentation is the basis for the production of many pharmaceutical products including anti-cancer cytotoxic drugs and vaccines. Microbial expression systems are used in the cosmetics industry due to their interesting skin- and hair-care functions and their potential to replace the enzymes harmful synthetic compounds. Biotech ingredients have excellent properties of Biocompatibility, eco-friendly nature, versatile activity and the superior performance drives the demand in cosmetic industry. White biotechnology makes use of fermentation technology from microorganisms at commercial level. For instance, Hyaluronic acid supplements can help increase skin moisture and reduce the appearance of fine lines and wrinkles is prepared using microbial expression systems. Initially, Hyaluronic acid was extracted from rooster combs, and are now mainly used to produce microbial fermentation for lower production costs and less environmental pollution.

Biotech Ingredients Market Segment Analysis – By End-Use Industry

The pharmaceuticals segment held the largest share in the biotech ingredients market in 2021. Biotech ingredients are useful in developing new product, with advanced processes. Biotech ingredients are used in the development of therapeutic drugs made of bioformulations like, antibodies, nucleic acids and others.  For instance, mammalian expression systems have properties like, highest-level protein processing, robust optimized transient systems and others. Therefore, can be used to produce mammalian proteins which are further used for the production of antibodies, complex proteins and others. Similarly, there are many processes through which chemical compounds made by bacteria, yeast and other expression systems are made into biotech ingredients. For instance, fermentation, where microorganisms such as bacteria, yeast and others are used to produce biotech ingredients. Through Fermentation, microorganisms are used to convert substrates such as glucose to products such as amino acids and antibodies. Recombinant DNA is the genetically engineered DNA created by combination of DNA of different organisms to produce Recombinant DNA products like Vaccines. Thus, biotech ingredients are used widely in the pharmaceutical industry for preventing, diagnosing of various diseases.

Biotech Ingredients Market Segment Analysis – By Geography

Europe region held the largest share in the biotech ingredients market in 2021 up to 45%, owing to the accelerating cosmetic industry in the region. This is because, cosmetics products have been growing in demand across Europe, presenting good opportunities for biotech ingredients exporters in developing countries. Companies are discarding the use of synthetic materials and replacing with biotech ingredients due to the shift of consumer preference towards sustainable raw materials. It was found that consumers are avoiding chemicals such as parabens, phthalates and others due to their harmful effects on skin such as the skin can get brittle, cracked and swollen. This trend is driving the demand for biotech ingredients such as oleoresins, essential oils, vegetable or animal derived oils, fats and others. Essential oils are mainly used as fragrances in skincare products such as serums, vegetable oils like argan oil, coconut oil is used in haircare products because of their nourishing and emulsifying properties. Europe is an emerging market for essential oils due to the growing demand for aromatherapy products, as European consumers use aromatherapy products for improving their health. Essential oils are used in aromatherapy products because they have properties such as stress-relieving, anti-bacterial soothing and others. Thus, the demand for biotech ingredients is rising in Europe. There are few significant programs that were undertaken such as Commission Expert Group for bio-based products, Circular Economy Package, Europe 2020 strategy and Innovation Union Flagship Programme which is contributing to the growth of biotech ingredients market in the region. For instance, Carbios, one of the most advanced biotech companies is developing ways to produce eco-friendly plastics. In June 2020, Carbios has created recyclable plastic bottles using enzymes as the biotech ingredient.

Biotech Ingredients Market Drivers

• Increasing demand from synthetic ingredients to biotech ingredients

There is a notable shift in demand towards biotech or organic ingredients because of the rising awareness in consumers regarding the harmful effects of synthetic products which is driving the biotech Ingredients market. Biotech ingredients are preferred as the production of biotech products that are eco-friendly, sustainable and efficacious obtained directly from microbes, yeast and others. 

• Flourishing White Biotechnology

White biotechnology, which is also known as industrial biotechnology, involves the use of microorganism and enzymes to make biotech ingredients such as APIs to be used in various biotech products. For instance, in pharmaceutical industry, huge efforts are been taken to develop vaccines, antibody tests, anti-virus drugs and others which is driving the biotech ingredient market. Industrial biotechnology is one of the most sustainable approaches towards, pollution prevention, resource conservation, cost reduction. The use of biotech ingredients can reduce the carbon dioxide emissions by as much as 50%, energy consumption by 20% and water consumption by 75%. 

Biotech Ingredients Market Challenges

• Higher Price of Biotech Ingredients

The increasing cost of healthcare, is majorly due to drugs as biotech ingredients used in the production of drugs or antibodies is expensive than synthetic ingredients. The reason behind the high cost of biotech ingredient is due to the following factors; production cost needed for producing biotech ingredients, the machinery and the equipment cost which are used in manufacturing, and the high expenses incurred during the development, testing and launching of products in the market.  Owing to these factors, the products which use Biotech ingredients comes with a higher price as compared to its alternative materials, which tends to constrain the growth of the market.

Biotech Ingredients Market Landscape

Technology launches, acquisitions, and R&D activities are key strategies adopted by players in the Biotech Ingredients market. Biotech Ingredients Market top companies are

1. Pfizer Inc.
2. Novartis International AG
3. Merck & Co.
4. Teva Pharmaceutical Industries Ltd.
5. Mylan Inc.
6. Boehringer Ingelheim
7. Sanofi
8. AbbVie
9. Eli Lilly and Company
10. AstraZeneca plc.

Acquisitions/Technology Launches

• In November 2021, Pfizer Inc and BioNTech SE announced their mRNA-based vaccine, BNT162b2, against Covid-19.  It is composed of biotech ingredient Nucleoside-modified mRNA encoding a mutated form of the full-length spike protein of SARS-CoV-2, encapsulated in Lipid nanoparticles.
• In November 2020, Merck, a major player in biotech ingredients market, announced that it will acquire Biotech Company VelosBio for USD$2.75 billion to expand its cancer treatment portfolio. Merck will take up VelosBio’s leading experimental drug to selectively send a toxic chemical to cancer cells by antibodies and hence safely avoiding the healthier cells.

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